Table 1.
Effects of metformin and atorvastatin on laboratory parameters
| Variables | Sham | Control | Atorvastatin | Metformin | Combined |
|---|---|---|---|---|---|
|
Initially |
|
|
|
|
|
|
TG (mmol/L) |
0.97 ± 0.10 |
0.96 ± 0.12 |
0.95 ± 0.12 |
0.96 ± 0.11 |
0.94 ± 0.12 |
|
TC (mmol/L) |
3.12 ± 0.28 |
3.15 ± 0.30 |
3.18 ± 0.32 |
3.16 ± 0.32 |
3.19 ± 0.29 |
|
LDL-C (mmol/L) |
1.97 ± 0.20 |
1.98 ± 0.20 |
1.99 ± 0.22 |
1.96 ± 0.18 |
2.00 ± 0.18 |
|
HDL-C (mmol/L) |
1.05 ± 0.05 |
1.07 ± 0.04 |
1.06 ± 0.04 |
1.06 ± 0.05 |
1.06 ± 0.05 |
|
CRP (mg/L) |
1.34 ± 0.18 |
1.37 ± 0.15 |
1.36 ± 0.15 |
1.35 ± 0.17 |
1.37 ± 0.16 |
|
ALT (U/L) |
26.2 ± 3.2 |
26.7 ± 3.1 |
27.2 ± 2.9 |
27.1 ± 2.4 |
26.8 ± 2.2 |
|
AST (U/L) |
27.7 ± 2.6 |
27.9 ± 2.1 |
28.0 ± 2.5 |
28.3 ± 3.0 |
27.8 ± 2.0 |
|
CK (U/L) |
13.3 ± 1.4 |
13.7 ± 1.2 |
14.2 ± 1.0 |
14.0 ± 1.2 |
13.5 ± 1.1 |
|
FBG (mmol/L) |
4.64 ± 0.37 |
4.57 ± 0.32 |
4.68 ± 0.30 |
4.66 ± 0.33 |
4.74 ± 0.25 |
|
6 weeks later |
|
|
|
|
|
|
TG (mmol/L) |
0.99 ± 0.10* |
2.18 ± 0.31 |
2.17 ± 0.30 |
2.18 ± 0.22 |
2.18 ± 0.21 |
|
TC (mmol/L) |
3.11 ± 0.29* |
5.87 ± 0.57 |
5.90 ± 0.60 |
5.93 ± 0.62 |
5.91 ± 0.59 |
|
LDL-C (mmol/L) |
1.95 ± 0.18* |
3.83 ± 0.53 |
3.84 ± 0.51 |
3.82 ± 0.50 |
3.79 ± 0.50 |
|
HDL-C (mmol/L) |
1.08 ± 0.05 |
1.09 ± 0.05 |
1.08 ± 0.04 |
1.08 ± 0.04 |
1.09 ± 0.05 |
|
CRP (mg/L) |
1.35 ± 0.12* |
7.87 ± 1.02 |
7.90 ± 1.06 |
7.88 ± 1.05 |
7.92 ± 1.02 |
|
ALT (U/L) |
28.4 ± 3.0 |
29.7 ± 3.1 |
29.7 ± 2.2 |
28.8 ± 1.0 |
28.8 ± 1.6 |
|
AST (U/L) |
28.0 ± 3.1 |
28.5 ± 2.2 |
28.1 ± 2.1 |
28.4 ± 2.2 |
28.4 ± 1.6 |
|
CK (U/L) |
13.9 ± 1.2 |
13.2 ± 1.0 |
14.0 ± 1.1 |
13.7 ± 1.2 |
13.3 ± 1.5 |
|
FBG (mmol/L) |
4.79 ± 0.42 |
5.83 ± 0.38 |
5.86 ± 0.35 |
5.92 ± 0.35 |
5.81 ± 0.28 |
|
4 weeks of intervention |
|
|
|
|
|
|
TG (mmol/L) |
0.97 ± 0.11* |
2.19 ± 0.21 |
1.93 ± 0.10 |
2.17 ± 0.18 |
1.93 ± 0.12 |
|
TC (mmol/L) |
3.02 ± 0.22* |
5.74 ± 0.36# |
4.60 ± 0.38 |
5.79 ± 0.37 |
4.52 ± 0.37 |
|
LDL-C (mmol/L) |
1.91 ± 0.15* |
3.72 ± 0.26# |
2.91 ± 0.28 |
3.73 ± 0.33 |
2.86 ± 0.16 |
|
HDL-C (mmol/L) |
1.07 ± 0.04 |
1.08 ± 0.04 |
1.09 ± 0.03 |
1.09 ± 0.03 |
1.10 ± 0.04 |
|
CRP (mg/L) |
1.36 ± 0.10* |
7.22 ± 1.06# |
5.18 ± 0.98 |
5.27 ± 0.78 |
4.53 ± 0.73& |
|
ALT (U/L) |
27.6 ± 2.1 |
27.9 ± 1.1 |
28.5 ± 2.2 |
28.2 ± 1.1 |
28.0 ± 2.1 |
|
AST (U/L) |
27.9 ± 2.2 |
28.2 ± 2.0 |
28.6 ± 2.1 |
28.3 ± 1.8 |
27.9 ± 1.2 |
|
CK (U/L) |
14.6 ± 1.1 |
13.8 ± 1.2 |
14.3 ± 1.2 |
14.2 ± 1.1 |
13.9 ± 1.2 |
| FBG (mmol/L) | 4.77 ± 0.46 | 5.71 ± 0.45 | 5.72 ± 0.43 | 4.98 ± 0.39 | 5.05 ± 0.45 |
Denote: *P < 0.05 sham group versus other group, #P < 0.05 control group versus atorvastatin and combined groups, &P < 0.05 combined group versus atorvastatin and metformin groups.