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. 2014 Jul 21;14:58. doi: 10.1186/1471-2253-14-58

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Copyright © 2014 Salazar et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Least mean squares estimates of regional cerebral oxygen saturation (rSO₂) in each hemisphere over time for all patients (n = 125). rSO₂ values for both hemispheres were seen to decrease over the course of study (P < 0.0001). The largest rSO₂ decline coincided with tourniquet deflation and reperfusion of the extremity. Three hours after surgery rSO₂ had not recovered to baseline (59.46% [95% CI, 58.25%–60.66%] and 59.20% [95% CI, 58.14%–60.27%] (P < 0.001) for right and left hemispheres respectively. CI = confidence interval. Ind = induction. Tourn = tourniquet. Postop = postoperative.