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. Author manuscript; available in PMC: 2014 Jul 24.
Published in final edited form as: Biochem Biophys Res Commun. 2006 Aug 28;349(2):533–539. doi: 10.1016/j.bbrc.2006.08.108

Figure 5. A schematic of the proposed mechanism whereby CD38 negatively regulates osteoclast formation.

Figure 5

Contaminating lymphocytes, which highly express CD38, act as a NADase to cleave NAD+ present in the media into ADPribose. It is possible that a signal that increases the cyclase activity of CD38, or possibly CD157, may produce cyclic ADPribose, which will serve to enhance osteoclast formation.

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