Fig. 2.

Antidepressant-like effect of xanthone derivatives in mice following forced swim test. Data are represented as the mean seconds (SEM) of the total swim period during a 6-minute session. Xanthone derivatives 1101 and 1105 were administered 1 hour before testing and venlafaxine hydrochloride was administered 45 minutes before testing. Each group contained 8 to 9 mice. ^*P < 0.05; ^†P < 0.01; ^‡P < 0.001 versus vehicle-treated mice; ^§P < 0.05; ^ǁP < 0.01 versus venlafaxine hydrochloride-treated mice.