Fig. 3.

Effects of xanthone derivatives in the rat forced swim test. Data are represented as the mean seconds (SEM) of the total swim period during the final 8 minutes of a 12-minute session. Xanthone derivatives 1101 and 1105 were administered 1 hour before testing and venlafaxine hydrochloride was administered 45 minutes before testing. Each group contained 8 or 9 rats. ^*P < 0.05; ^†P < 0.01; ^‡P < 0.001 versus vehicle-treated rats; ^§P < 0.05; ^¶P < 0.001 versus venlafaxine hydrochloride-treated rats.