Fig. 4.

Antidepressant-like effects of xanthone derivatives on tail suspension tests with mice. Data are represented as the mean seconds (SEM) of the total activity period during a 6-minute session. Xanthone derivatives 1101 and 1105 were administered 1 hour before testing and venlafaxine hydrochloride was administered 45 minutes before testing. Each group contained 8 or 9 mice. ^†P < 0.01; ^‡P < 0.001 versus vehicle-treated mice; ^ǁP < 0.01; ^¶P < 0.001 versus venlafaxine hydrochloride-treated mice.