Table I.
ANOVA results for mice forced swim test (MFST) and mice tail suspension test (MTST) following administration of substances.
| Mouse groups |
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|---|---|---|---|---|
| Vehicle,* venlafaxine (16 mg/kg), and derivative 1101 (6.25, 12.5, and 25 mg/kg) |
Vehicle,* venlafaxine (16 mg/kg), and derivative 1105 (6.25, 12.5, and 25 mg/kg) |
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| Test | F | P | F | P |
| MFST | 8.235 | 0.000 | 5.496 | 0.001 |
| MTST | 14.495 | 0.000 | 18.009 | 0.000 |
Vehicle (negative control) group received a single oral dose of 0.5% hydroxymethyl cellulose aqueous solution.