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σ1R agonists inhibit voltage-gated calcium current in control sensory neurons. After whole-cell configuration, the ICa was measured with a square wave voltage command (holding potential at −90 mV and step to 0 mV for 100 milliseconds) using Ba2+ as charge carrier. PTZ (A) reduced ICa (sample traces, top panel; averaged time data, bottom panel) in a dose-related fashion (B), as did DTG (C and D). N = 4–10 for each concentration.
