NMDAR activity of spinal dorsal horn neurons is dynamically controlled by CK2 and calcineurin. (A and B) Representative recordings (A) and mean changes (B) in the amplitude of evoked NMDAR-EPSCs and AMPAR-EPSCs of lamina II neurons in control rat spinal slices treated with vehicle (dimethylsulfoxide, n = 13 neurons), 1 μM FK-506 (n = 10 neurons), 0.1 μM okadaic acid (n = 12 neurons), FK-506 plus DRB (n = 10 neurons), or FK-506 plus TBB (n = 10 neurons). (C) Mean changes in the amplitude of evoked NMDAR-EPSCs and AMPAR-EPSCs of lamina II neurons in SNL rat spinal cord slices treated with vehicle (n = 16 neurons) or 1 μM FK-506 (n = 14 neurons). *P < 0.05 compared with the vehicle control group. Error bars represent the S.E.M.