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. 2014 Aug;350(2):301–312. doi: 10.1124/jpet.114.215855

Fig. 8.

Fig. 8.

NMDAR activity of spinal dorsal horn neurons is dynamically controlled by CK2 and calcineurin. (A and B) Representative recordings (A) and mean changes (B) in the amplitude of evoked NMDAR-EPSCs and AMPAR-EPSCs of lamina II neurons in control rat spinal slices treated with vehicle (dimethylsulfoxide, n = 13 neurons), 1 μM FK-506 (n = 10 neurons), 0.1 μM okadaic acid (n = 12 neurons), FK-506 plus DRB (n = 10 neurons), or FK-506 plus TBB (n = 10 neurons). (C) Mean changes in the amplitude of evoked NMDAR-EPSCs and AMPAR-EPSCs of lamina II neurons in SNL rat spinal cord slices treated with vehicle (n = 16 neurons) or 1 μM FK-506 (n = 14 neurons). *P < 0.05 compared with the vehicle control group. Error bars represent the S.E.M.