Fig. 6.

1Z88 and 1Z105 prevent the onset of innate inflammatory arthritis. Groups (n = 6) of mice were injected with pooled arthritogenic KRN sera intraperitoneally. Mice received every other day treatment with vehicle, 0.50 µmol i.p. 1Z88. An additional group received 5 µmol 1Z105 by gavage. Paw swelling (A) was measured and the arthritis was clinically (B) scored daily. Data shown are mean ± S.E.M. of pooled two independent experiments. *P < 0.001; **P < 0.01 were determined by the Kruskal–Wallis method for area under the curve values for individual mice. (C) On day 10 the mice were killed, one hind paw per mouse was prepared for histology, and sections were stained with H&E [for inflammation (☆) and erosion (▵)] and toluidine blue (for cartilage damage, ▴). The inflammation, erosion, and cartilage scores were statistically lower in the 1Z88 and the 1Z105 treated mice. *P < 0.05; **P < 0.01 by one-way analysis of variance with Dunnett’s post hoc testing. Shown are examples (50× magnification) of H&E and toluidine blue stained talonavicular joints of the vehicle- (D and E), 1Z88- (F and G), and 1Z105- (H and I) treated animals.