TABLE 1.
Patients dosed with diclofenac
The complete lists of comedications are recorded in Supplemental Table 3. A blank entry signifies that none of the comedications is known to form an AG metabolite in humans.
| Patient | Diclofenac Doses and Formulationsa | Blood Sampling after Last Diclofenac Dose | Comedications Metabolized to AG in Humansb |
|---|---|---|---|
| hrs | |||
| N01 (male, 42 yr) | 50 mg, b.i.d. (EC) | 1 | |
| N02 (female, 65 yr) | 50 mg, b.i.d. (EC) | 1 | |
| N03 (female, 52 yr) | 50/75 mg AM/PM (EC/MR) | 1 | |
| N08 (male, 63 yr) | 50 mg, t.i.d. (EC) | 3 | aspirin, ramipril rosuvastatin |
| N09 (male, 48 yr) | 50 mg, t.i.d. (EC) | 2.5 | simvastatin |
| N10 (female, 77 yr) | 50 mg, t.i.d. (Voltarol dispersible tablets) | 2.5 |
EC, enteric-coated; MR, modified release.
a
Diclofenac sodium formulations except where indicated. All the patients had taken diclofenac for at least 1 year.
b
AG metabolites of comedications are formed in vivo and/or in vitro.