. 2014 Aug;350(2):425–434. doi: 10.1124/jpet.114.213470

TABLE 2.

Gestational age–dependent AUCs of glyburide and metabolites in maternal plasma using noncompartmental analyses

Data are reported as the mean (95% confidence interval). The metabolite/glyburide AUC ratios were corrected for differences in the molarity between glyburide (494 g⋅mol⁻¹) and metabolites (510 g⋅mol⁻¹).

Parameter	gd 0	gd 7.5		gd 10		gd 15		gd 19
Parameter	Mean	Mean	P Value	Mean	P Value	Mean	P Value	Mean	P Value
GLY AUC_{0–240 min} (ng⋅min⋅ml⁻¹)	55,169 (46,859–65,378)	39,729 (32,827–46,781)^a	0.013^a	29,308 (25,112–33,771)^a	<0.001^a	25,302 (19,276–31,635)^a	<0.001^a	24,216 (19,689–30,361)^a	<0.001^a
M1 AUC_{0–240 min} (ng⋅min⋅ml⁻¹)	251 (204–294)	187 (156–219)	0.084	232 (205–258)	0.596	129 (88–172)^a	0.006^a	141 (114–163)^a	0.011^a
M2a AUC_{0–240 min} (ng⋅min⋅ml⁻¹)	359 (305–401)	221 (166–265)^a	0.001^a	256 (206–295)^a	0.007^a	101 (61–149)^a	<0.001^a	131 (97–169)^a	<0.001^a
M2b AUC_{0–240 min} (ng⋅min⋅ml⁻¹)	238 (208–274)	159 (134–188)^a	0.009^a	141 (112–177)^a	0.005^a	47 (30–63)^a	<0.001^a	83 (66–99)^a	<0.001^a
M3 AUC_{0–240 min} (ng⋅min⋅ml⁻¹)	251 (223–285)	188 (148–237)^a	0.044^a	137 (107–170)^a	0.002^a	50 (32–67)^a	<0.001^a	70 (57–82)^a	<0.001^a
M1/GLY AUC ratio (%)	0.44 (0.37–0.51)	0.46 (0.37–0.55)	0.793	0.77 (0.67–0.88)^a	<0.001^a	0.49 (0.36–0.64)	0.534	0.57 (0.43–0.69)	0.091
M2a/GLY AUC ratio (%)	0.63 (0.53–0.71)	0.54 (0.40–0.67)	0.270	0.85 (0.70–0.98)^a	0.028^a	0.39 (0.25–0.55)^a	0.036^a	0.53 (0.38–0.70)	0.298
M2b/GLY AUC ratio (%)	0.42 (0.35–0.48)	0.39 (0.32–0.47)	0.576	0.47 (0.37–0.57)	0.485	0.18 (0.12–0.24)^a	0.003^a	0.33 (0.25–0.42)	0.231
M3/GLY AUC ratio (%)	0.44 (0.37–0.51)	0.46 (0.36–0.60)	0.767	0.45 (0.36–0.55)	0.867	0.19 (0.13–0.25)^a	0.003^a	0.28 (0.21–0.35)^a	0.041^a

GLY, glyburide.

^{^a}

Parameters on gd 7.5, 10, 15, or 19 with statistically significant (P < 0.05) differences versus gd 0.