Table 1.
Subjects’ characteristics and distribution according to the genotype of rs3134105
| NR | AA (n = 12) | AG (n = 39) | GG (n = 32) | p value | |
|---|---|---|---|---|---|
| Age at diagnosis, years | NA | 49 (21–72) | 48 (14–72) | 48 (21–75) | 0.9916 |
| Age, years | NA | 60 (32–83) | 54 (18–79) | 55.5 (29–81) | 0.8412 |
| Histology, NA | NA | 11 P; 1 F | 39 P | 26 P, 4 F; 2 H | NA |
| Weight, kg | NA | 78.5 (42–104) | 71 (51.5–135.5) | 69.5 (52–115.5) | 0.7084 |
| BMI, kg/m2 | 18–25 | 25.56 (17.71–40.12) | 25.81 (18.21–42.77) | 25.02 (20.45–33.38) | 0.3368 |
| TSH, μIU/ml | 0.35–4.94 | 0.10 (0.01–0.18) | 0.08 (0.01–0.29) | 0.12 (0.02–0.28) | 0.0411 |
| fT3, pmol/l | 2.6–5.7 | 4.54 (3.23–5.38) | 4.46 (3.38–5.38) | 4.31 (3.38–5.54) | 0.5858 |
| fT4, pmol/l | 9–19.2 | 16.79 (14.74–20) | 16.67 (14.23–22.56) | 15.64 (12.31–24.74) | 0.1604 |
| Ab anti-TG, IU/ml | 0–60 | 19.85 (1–46.90) | 28.40 (1–48.20) | 23.90 (14–29) | 0.4832 |
| LT4 dose, μg/day | NA | 110.71 (64.28–175) | 132.14 (85.71–200) | 103.57 (78.57–225) | 0.1348 |
| LT dose/kg, μg/kg/day | NA | 1.42 (1.12–2.64) | 1.62 (0.93–2.95) | 1.53 (1.22–2.44) | 0.4233 |
| fT3/fT4, NA | NA | 0.28 (0.19–0.32) | 0.27 (0.20–0.34) | 0.27 (0.15–0.38) | 0.7627 |
| fT3/TSH, NA | NA | 57.44 (24.85–369.23) | 55.77 (13.79–523.01) | 34.96 (12.53–200) | 0.0511 |
| fT4/TSH, NA | NA | 200 (81.91–1,525.64) | 224.18 (51.74–1,794.87) | 122.54 (57.20–839.74) | 0.0211 |
Data were analyzed using the Kruskal-Wallis test and Dunn's post-test for multiple comparison. p was considered significant when <0.05. Results are expressed as median (min–max). NR = Normal range; NA = not applicable; AA = homozygotes adenine-adenine; AG = heterozygotes adenine-guanine; GG = homozygotes guanine-guanine; P = papillary; F = follicular; H = Hurtle cells.