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. 2014 Jun 24;124(8):3551–3565. doi: 10.1172/JCI75334

Figure 1. Somatic deletion of Recql4 causes anemia and leucopenia.

Figure 1

(A) Schematic for the deletion strategy used in 7-week-old mice using R26-CreERT2 and genomic PCR demonstrating deletion of Recql4 in BM. (B) Leukocyte counts in the PB of control (+/+) and Recql4 deficient (Δ/Δ) mice. (C) Absolute numbers of leukocyte subsets in PB. (D) Platelet count. (E) rbc count. (F) Hemoglobin. (G) Hematocrit. (H) images of BM flushes from the indicated genotypes. (I) Representative histology of the tibia from epiphysis (region 1); trabecular region (arrowheads indicated adipocytes; region 2); and cortical region (region 3) of the bone. Scale bars: 50 μm; 20 μm (higher power image, region 3). Data expressed as mean ± SEM, Student’s t test. *P < 0.05; **P < 0.01. n ≥ 5 per genotype. Experiments were independently performed on at least 3 separate cohorts, with results pooled for presentation.