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. 2014 Jun 24;124(8):3551–3565. doi: 10.1172/JCI75334

Figure 9. Concurrent p53 deletion does not modify the RECQL4 deficient phenotype.

Figure 9

(A) Schematic of analysis of Recql4 p53 double mutants. (B) PB leukocyte and rbc counts. (C) BM cellularity. (D) HSC and MPP number per femur. (E) BM B cell populations. (F) BM erythroid populations based on CD71/Ter119 staining. (G) Thymus cellularity. (H) Thymic CD4/CD8 populations. There are no statistical differences between the R26-CreER Recql4Δ/Δ and R26-CreER Recql4Δ/Δp53Δ/Δ (dKO) for any of the parameters assessed at day 30 of analysis. Data expressed as mean ± SEM, ordinary 1-way ANOVA with multiple comparisons test. Statistical comparison only shown for Recql4Δ/Δ versus dKO. Full statistical analysis of all comparisons in Supplemental Table 2. n ≥ 4 per genotype.