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. 2014 Jul 8;124(8):3601–3611. doi: 10.1172/JCI74134

Figure 2. Disruption of the interaction of RAS with PI3K in the host reduces tumor growth.

Figure 2

B16F10 (A–C) and LLC1 (D–F) cells were injected into the indicated mice. (A and D) Tumor volumes, measured by caliper over time. n = 11 (A); 6 (D). (B and E) Tumor volume 18 (B) or 21 (E) days after cell injection. Horizontal bars represent the median. Mann-Whitney nonparametric statistical analysis was performed. (C and F) Overall survival. The endpoint of the analysis was set in 2 cm of length in any direction, as stated in the approved Animal Project License. Kaplan-Meier survival curves are shown. Mantel-Cox (Log-rank) statistical analysis was performed. n = 6 (C); 6 (F, WT/– and MUT/–); 10 (F, WT/fl and MUT/fl).