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. 2014 Jul 8;124(8):3601–3611. doi: 10.1172/JCI74134

Figure 3. Disruption of the interaction of RAS with PI3K in the host reduces metastasis.

Figure 3

(A) Luciferase activity of B16F10 cells injected in the tail vein was measured ex vivo 21 days after injection. Bars represent the median. Mann-Whitney nonparametric statistical analysis was performed. (B) H&E staining of lung sections. Arrows indicate diffuse nodules in the periphery of the lung. Scale bars: 1,000 μm (left); 100 μm (right). (C) Number of tumor foci per whole lung. (D) Tumor area, expressed as a percentage of total lung area. (E) Average foci area, expressed as a percentage of lung area. (C–E) Mann-Whitney statistical analysis was performed. n = 6 per group.