Figure 10. Integrin α1β1 controls TβRII-mediated cell morphology and collagen production.

(A) In CD cells, activation of integrin α1β1 leads to recruitment and activation of TCPTP. This results in reduced tyrosine phosphorylation of TβRII, reduced activation of TβRI, and reduced SMAD2/3 phosphorylation. Ultimately, recruitment of TCPTP by integrin α1β1 negatively regulates TβRI/TβRII-mediated collagen production and EMT. (B) In the absence of integrin α1β1, loss of TCPTP activation promotes collagen production and EMT by increasing tyrosine phosphorylation of TβRII, activation of TβRI, and SMAD2/SMAD3 phosphorylation.