Figure 4. Effects of treatment on network modulation under the blind.

Changes in SSRP expression (light gray bars) were computed under the blind at 6 months in the 16 sham responders and 14 STN AAV-GAD gene therapy responders (see text). Concurrent changes in UPDRS motor scores (dark gray bars) are presented for comparison. Motor outcomes under the blind did not differ for the GAD_R and SHAM_R subjects [t(28) = 1.213, P = 0.235]. Nonetheless, a significant difference in SSRP modulation was observed in the 2 groups [t(28) = 3.379, P = 0.002].