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. 2014 Jul 24;8:196. doi: 10.3389/fncel.2014.00196

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Copyright © 2014 Wilson, Moutal, Melemedjian, Wang, Ju, François-Moutal, Khanna and Khanna.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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KCl-induced activity decreases Cdk5-phosphorylated CRMP2. (A) Timeline of experimental procedures. (B) Schematic of GSK3β and Cdk5 phosphorylation sites within the rat CRMP2 sequence. Numbers represent amino acid residues within the CRMP2 sequence. (C) Representative immunoblots of Cdk5-phosphorylated CRMP2 (CRMP2 pSer522) and β III-tubulin from naïve cortical neurons compared to those exposed to KCl for 30 min or 96 h. (D) KCl exposure lead to a time-dependent decrease in the level of Cdk5-phosphorylated CRMP2 (CRMP2 pSer522) (^*p < 0.05 compared to control and ^#p < 0.05 compared to 30 min KCl treatment; One-Way ANOVA, Tukey's post-hoc analysis; n = 5).