Table 1.
Comparison of the ability of lacosamide derivatives to affect VGSC and CRMP2 function.
| Compound | Structure | Slow inactivation IC50 (μM)a | Total outgrowth (% of vehicle)b |
|---|---|---|---|
| (R)-LCM |  |
85 | 81.6 ± 3.7* |
| (S)-LCM |  |
>1000 | 66.2 ± 5.9* |
| Derivative 1 |  |
>2400 | 95.8 ± 4.3 |
| Derivative 2 |  |
>1000 | 98.0 ± 4.5 |
a
Slow inactivation IC50 values were obtained from previous reports (Brittain et al., 2009; Sun et al., 2010).
b
Total outgrowth represents outgrowth following a 24 h incubation in 300 μM of each compound. For ease of comparison, values were normalized to vehicle.
*
(p < 0.05 vs. vehicle) (Student's t-test) (values represent mean ± s.e.m.) (n = 263–394 cells from 8 separate culture wells).