Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Aβ and Notch IC50 values.
| Assay (cell line) | BMS-869780 (GSM) | BMS-299897 (GSI ) | BMS-433796 (GSI) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| IC50 (nM) | sd | n | IC50 (nM) | sd | n | IC50 (nM) | sd | n | |
| Aβ1-42 (H4-APPsw) | 5.1 | 2.2 | 13 | 0.47 | 0.61 | 322 | 0.16 | 0.08 | 256 |
| Aβ1-40 (H4-APPsw) | 24.1 | 7.7 | 7 | 1.3 | 1.2 | 93 | 0.19 | 0.14 | 20 |
| Aβ1-42 (MEF PS1wt) | 7.7 | 2.3 | 2 | ||||||
| Aβ1-40 (MEF PS1wt) | 11 | 4 | 2 | ||||||
| Aβ1-42 (MEF M146V) | 22 | 1.4 | 2 | ||||||
| Aβ1-40 (MEF M146V) | 34 | 9 | 2 | ||||||
| mNotch1ΔE (luciferase) | >10000 | 3 | 340 | 108 | 147 | 2.1 | 1.0 | 256 | |
| mNotch1ΔE/Aβ1-42 | >1785x | 723x | 13x | ||||||
