Table 3.

Relationship between dose, plasma AUC, and Aβ ABEC.

Dose	Plasma AUC0–24 hr	Brain Aβ ABEC24 hr
	(μM·h)	Aβ1-42 (%)	Aβ1-40 (%)
Mouse 30 mg/kg PO solution (observed 0–24 hours)	45.9	30.9	n.d.
Mouse 100 mg/kg PO solution (observed 0–24 hours)	102	55.1	n.d.
Rat 10 mg/kg PO solution (observed 0–24 hours)	46.3	47.0	46.1
Rat 3 mg/kg PO solution (predicted steady state after 3 daily doses)∗	18.6	26.9
Human 700 mg PO suspension (predicted steady state)∗	17.8	25

*Dose predicted to achieve Aβ42 ABEC of ca. 25%.