Table 5.
Summary of exposure in rat 4-day dosing experiment.
| Dose (mg/kg) |
Male | Female | ||
|---|---|---|---|---|
| Day 1 | Day 3 | Day 1 | Day 3 | |
| C max (μM) | ||||
| 10 | 2.0 (±0.4) | 1.9 (±0.46) | 2.9 (±0.4) | 2.6 (±0.06) |
| 30 | 6.1 (±1.8) | 10.4 (±2.0) | 8.2 (±1.7) | 14.4 (±1.0) |
| 100 | 7.7 (±0.9) | 13.2 (±1.5) | 10.6 (±1.0) | 15.5 (±2.3) |
|
| ||||
| AUC (0–24 h) (μM·h) | ||||
| 10 | 20.2 (±4.8) | 17.5 (±5.7) | 41.0 (±5.6) | 25.0 (±1.5) |
| 30 | 95.2 (±19.9) | 128.6 (±65.0) | 152.2 (±21.0) | 255.1 (±28.5) |
| 100 | 167.5 (±14.5) | 216.9 (±80.5) | 205.9 (±43.2) | 316.4 (±77.0) |
|
| ||||
| T max (h) | ||||
| 10 | 5.0 (±2.0) | 5.0 (±2.0) | 7.0 (±2.0) | 5.0 (±2.0) |
| 30 | 8.0 (±0.0) | 3.0 (±1.0) | 5.0 (±2.0) | 3.0 (±1.0) |
| 100 | 19.0 (±9.0) | 7.0 (±2.0) | 24 (±0.0) | 4.0 (±4.0) |
|
| ||||
| Dose (mg/kg) |
Terminal concentration day 4 (μM) | |||
| Male | Female | |||
|
| ||||
| 10 | 2.4 (±0.6) | 3.0 (±0.3) | ||
| 30 | 8.9 (±1.9) | 12.0 (±4.6) | ||
| 100 | 9.2 (±3.2) | 13.7 (±0.9) | ||