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. Author manuscript; available in PMC: 2015 Aug 22.
Published in final edited form as: Neuroscience. 2014 Jun 5;274:341–356. doi: 10.1016/j.neuroscience.2014.05.056

Figure 7.

Figure 7

Comparisons of endpoints obtained in this study. Top. Both fenfluramine-stimulated PRL secretion (PRL AUC) and the density of serotonin pixels in the LC (LC 5HT) declined with decreased E in the brain due to castration or aromatase block. There was a trend toward correlation between the AUC of fenfluramine-stimulated prolactin secretion and the serotonergic innervation of the LC (F [1,4] = 10.71; r2 = 0.821; p = 0.08). Bottom. Basal PRL, TPH2 gene expression and SERT gene expression all showed stimulation with androgen treatment, either with T or DHT. Aromatase block had no effect on basal PRL, TPH2 expression or SERT expression. Regression analysis of prolactin secretion and TPH2 or SERT gene expression exhibited a positive trend (F [1,4]; r2=0.8; p~0.1). Regression analysis of TPH2 and yawning (F[1,2]=15.17; r2=0.88; p=0.06) and between SERT and yawning (F[1,2]=16.91; r2=0.88; p=0.054) also showed a positive trend (data not shown on graph).