Table 4.

Mean Changes from Baseline in Cardiovascular Risk Factors Among Women Receiving Nevirapine- and Lopinavir/ritonavir-Based Antiretroviral Therapy¹

Cardiovascular Risk Factor	week	NVP-based ART		LPV/RTV-based ART		Difference in Means
		No.	Mean±SE	No.	Mean±SE	Unadjusted (95% CI)	P	Adjusted (95% CI)	P
Total cholesterol (mg/dL)	48	262	19.1±1.8	322	29.4±1.8	−10.3 (−15.4, −5.3)	<.001	−9.2 (−14.1, −4.3)	<.001
	96	164	25.8±2.7	223	33.4±2.1	−7.5 (−14.2, −0.9)	0.027	−7.6 (−14.0, −1.2)	0.020
	144	57	34.1±4.0	90	41.1±3.2	−7.1 (−17.1, 3.0)	0.169	−8.3 (−17.9, 1.3)	0.090
HDL (mg/dL)	48	257	16.8±1.0	318	11.0±0.7	5.7 (3.4, 8.1)	<.001	5.8 (3.7, 7.9)	<.001
	96	164	18.5±1.3	224	12.9±0.9	5.7 (2.7, 8.7)	<.001	5.5 (2.7, 8.2)	<.001
	144	57	21.0±2.6	89	12.2±1.7	8.8 (3.0, 14.6)	0.003	8.5 (3.2, 13.8)	0.002
Non-HDL(mg/dL)	48	256	2.3±1.8	317	18.2±1.7	−15.9 (−20.8, −11.0)	<.001	−15.0 (−19.9, −10.2)	<.001
	96	164	7.3±2.6	223	20.5±1.9	−13.2 (−19.5, −6.9)	<.001	−13.1 (−19.3, −7.0)	<.001
	144	57	13.1±3.9	89	29.4±2.9	−16.3 (−25.7, −6.8)	<.001	−17.1 (−26.3, −8.0)	<.001
LDL (mg/dL)	48	257	5.9±1.5	315	15.1±1.5	−9.2 (−13.4, −5.0)	<.001	−8.6 (−12.7, −4.5)	<.001
	96	164	10.6±2.1	223	15.9±1.8	−5.3 (−10.7, 0.1)	0.054	−5.4 (−10.5, −0.2)	0.042
	144	56	16.5±3.7	89	23.2±2.7	−6.8 (−15.7, 2.2)	0.136	−6.8 (−15.5, 1.8)	0.118
Triglycerides (mg/dL)	48	263	−17.8±4.5	318	22.2±3.9	−40.1 (−51.8, −28.3)	<.001	−37.2 (−47.8, −26.6)	<.001
	96	163	−17.4±4.0	223	21.9±4.2	−39.3 (−51.1, −27.5)	<.001	−39.3 (−49.5, −29.1)	<.001
	144	57	−20.6±8.3	90	30.1±6.3	−50.7 (−71.0, −30.4)	<.001	−50.4 (−65.8, −35.0)	<.001
Body mass index (kg/m2)	48	272	2.0±0.2	330	1.3±0.1	0.7 (0.3, 1.1)	<.001	0.7 (0.3, 1.0)	<.001
	96	182	2.6±0.2	243	1.8±0.2	0.9 (0.3, 1.4)	0.002	0.9 (0.3, 1.5)	0.002
	144	75	3.3±0.4	108	2.1±0.3	1.2 (0.2, 2.1)	0.018	1.2 (0.2, 2.1)	0.014
Blood pressure-systolic(mmHg)	48	273	5.0±0.9	329	3.0±0.8	2.0 (−0.3, 4.4)	0.087	2.5 (0.5, 4.5)	0.016
	96	182	6.1±1.2	243	3.3±0.9	2.8 (−0.1, 5.8)	0.059	3.5 (0.9, 6.1)	0.008
	144	75	7.0±1.7	108	2.3±1.6	4.8 (0.1, 9.4)	0.044	5.7 (1.8, 9.7)	0.004
Blood pressure-diastolic(mmHg)	48	273	2.9±0.7	329	0.4±0.6	2.5 (0.8, 4.2)	0.005	2.8 (1.3, 4.2)	<.001
	96	182	3.6±0.9	243	0.0±0.7	3.6 (1.5, 5.8)	<.001	3.8 (2.0, 5.7)	<.001
	144	75	5.3±1.3	108	−0.5±1.0	5.8 (2.6, 9.0)	<.001	6.2 (3.4, 9.1)	<.001

¹Differences in means were evaluated using linear regression. Adjusted results are with adjustment for age, CD4 count, log10 HIV-1 RNA and cardiovascular risk factor at baseline included as continuous covariates. P-values are from Wald tests.

²Abbreviations: NVP, Nevirapine; LPV/RTV, Lopinavir/ritonavir; ART, antiretroviral therapy; SE, standard error (of the estimated mean); CI, confidence interval; HDL, high-density lipoprotein; LDL, low-density lipoprotein.