Table 1.

Summary of approaches to iNPC generation

Genes	Vector	Time	Efficiencies (method)	Multipotency	Self-renewal	Transgene dependence	Ref
Oct4, Sox2, Kl4, c-Myc	Endogenous induction/lentivirus	11 days	0.69% (Colonies)	Neuronal astrocytic	N	N	[19]
Oct4, Sox2, Klf4, c-Myc	Oct4 protein transduction, retrovirus	18 days	0.005–0.008% (Colonies)	Tripotent	?	N	[21•]
Ascl1, Ngn2, Hes1, Id1, Pax6, Brn2, Sox2, Klf4, c-Myc	Retrovirus	3 days	0.001–0.002% (Colonies)	Tripotent	?	Y	[23]
FoxG1, Sox2	Lentivirus	16 days	5% (FACS)	Neuronal astrocytic	Y	Y	[24•]
Brn2, FoxG1, Sox2	Lentivirus	21 days	11.5% (FACS)	Tripotent	Y	Y	[24•]
Brn4, Sox2, Klf4, c-Myc	Retrovirus	4–5 weeks	0.002–0.006% (Colonies)	Tripotent	?	N	[25•]