Table 3.
Comparison of chronic comorbidities among anal fissure cases versus age- and sex-matched controls (1 to 3 matching)
| |
Cases |
|
Controls |
|
|
|---|---|---|---|---|---|
| Description | N | % | N | % | P-value |
|
No. of patients* (% of cohort) |
1062 |
|
3186 |
|
|
|
Elixhauser comorbidities: |
|
|
|
|
|
| AIDS |
5 |
0.5% |
7 |
0.2% |
0.182 |
| Alcohol abuse |
24 |
2.3% |
97 |
3.0% |
0.183 |
| Chronic blood loss anemia |
12 |
1.1% |
38 |
1.2% |
0.870 |
| Coagulopathy |
14 |
1.3% |
43 |
1.4% |
0.939 |
| Congestive heart failure |
27 |
2.5% |
93 |
2.9% |
0.521 |
|
Constipation |
149 |
14.0% |
114 |
3.6% |
<0.001 |
| Deficiency anemias |
87 |
8.2% |
227 |
7.1% |
0.250 |
| Depression |
149 |
14.0% |
387 |
12.2% |
0.110 |
| Diabetes (no chr complication) |
147 |
13.8% |
402 |
12.6% |
0.303 |
| Diabetes (w/chr complications) |
30 |
2.8% |
117 |
3.7% |
0.191 |
| Drug abuse |
29 |
2.7% |
112 |
3.5% |
0.216 |
| Fluid and electrolyte disorders |
56 |
5.3% |
168 |
5.3% |
1.000 |
| Hypertension |
344 |
32.4% |
959 |
30.1% |
0.161 |
|
Hypothyroidism |
156 |
14.7% |
330 |
10.4% |
<0.001 |
| Liver disease |
34 |
3.2% |
84 |
2.6% |
0.332 |
| Lymphoma |
8 |
0.8% |
17 |
0.5% |
0.418 |
| Metastatic cancer |
12 |
1.1% |
23 |
0.7% |
0.203 |
|
Obesity |
138 |
13.0% |
246 |
7.7% |
<0.001 |
| Other neurological disorders |
48 |
4.5% |
161 |
5.1% |
0.486 |
| Paralysis |
7 |
0.7% |
24 |
0.8% |
0.755 |
| Peripheral vascular disease |
37 |
3.5% |
109 |
3.4% |
0.923 |
| Pregnancy |
72 |
6.8% |
276 |
8.7% |
0.053 |
| Psychoses |
99 |
9.3% |
256 |
8.0% |
0.189 |
| Pulmonary circulation disease |
23 |
2.2% |
60 |
1.9% |
0.565 |
| Renal failure |
29 |
2.7% |
84 |
2.6% |
0.869 |
| Rheumatoid arth./ col. vasc. dz |
37 |
3.5% |
120 |
3.8% |
0.673 |
|
Solid tumor - no metastasis |
55 |
5.2% |
118 |
3.7% |
0.035 |
| Valvular disease |
30 |
2.8% |
111 |
3.5% |
0.299 |
|
Weight loss |
40 |
3.8% |
54 |
1.7% |
<0.001 |
| Any Elixhauser diagnosis | 741 | 69.8% | 2091 | 65.6% | 0.013 |
*The case–control comparison is limited to adults age 18 and older because the Elixhauser comorbidity classification system is not validated in children.