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Expression of S1PRs and responses by neural cells. Neural progenitors express S1P1 and S1P2, neurons express S1P1 and S1P3, oligodendrocytes express S1P1 and S1P5, and astrocytes express S1P1 and S1P2. S1P1 couples exclusively to Gαi. S1P2 and S1P3 can couple to Gαi, Gα12/13, or Gαq, and S1P5 can couple to Gαi or Gα12/13. Cells do not necessarily express all of the illustrated S1PRs at one time, but may have differential expression during different stages of maturation or activation.
