TABLE 2.

Segregation of mutations in extreme HDL genes

Gene	Mutations (number of probands)	HDLp Mutation Carriers	HDLp Family Controls
GCKR	R232Q(2)+R518W(1)	85.1 (11.4) (21)	77.2 (22.1) (14); 0.004; 12.7
LILRA3	IVS1+0T>C(1)	86.4 (10.9) (7)	51.7 (30.4) (21); 0.036; 34.9
RNASEL	G179R(1)+E265X(1)	90.6 (11.1) (16)	71.3 (27.0) (33); 0.01; 20.1
DNAH10	IVS63+0 G>A(1)	95.8 (0.5) (4)	41.8 (33.1) (4); 0.04; 59.8

HDLp = HDLc percentile; values are average (standard deviation) (n); empirical P value following 1,000,000 permutations (in bold); beta.