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. 2014 Aug;55(8):1738–1749. doi: 10.1194/jlr.M050518

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Copyright © 2014 by the American Society for Biochemistry and Molecular Biology, Inc.

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Fig. 5. — Proposed integrated compartmental model for VA metabolism (model 2) in neonatal rats administered [³H]retinol in oil or in VARA. Compartments are represented as circles and interconnectivities between compartments correspond to L(I,J)s or the fraction of the material in compartment J transferred to compartment I per day. Compartment 26 represents the processing of newly ingested VA in the stomach, and 17 represents its processing in the intestine. Compartment 10 represents plasma retinyl ester in CM/CM remnants. Delay element 60 describes the time needed for the production of CM before their appearance in the plasma. Compartments 12, 13, 25, and 15 represent the uptake of plasma retinyl ester from CM/CM remnants into liver, lung, kidney, and carcass, respectively. Compartment 1 represents the plasma retinol pool. Compartments 2, 3, 4, 5, 6, and 7 represent VA pools in liver, lung, kidney, carcass, stomach, and intestine, respectively, that exchange VA with retinol in compartment 1. The asterisk represents the site of input of [³H]retinol and is also the site of input for dietary VA. IC(26) represents the newly ingested dose that enters the stomach.