TABLE 1.
The fractional transfer coefficients predicted by the forcing function model (model 1)
| L(I,J) | Tissue | Treatment Group | |
| Oil | VARA | ||
| Value (day−1; FSD) | |||
| L(12,10) | Liver | 168 (0.13) | 223 (0.06)a |
| L(0,12) | 50.0 (0.15) | 0.25 (0.58)a | |
| L(2,1) | 36.9 (0.05) | 28.1 (0.13) | |
| L(0,2) | 1.20 (0.06) | 0.38 (0.09)a | |
| L(13,10) | Lung | 2.68 (0.04) | 32.6 (0.03)a |
| L(0,13) | 4.07 (0.05) | 0.70 (0.07)a | |
| L(3,1) | 0.21 (0.04) | 0.14 (0.12)a | |
| L(0,3) | 0.16 (0.04) | 0.11 (0.14)a | |
| L(25,10) | Kidney | 3.22 (0.03) | 1.37 (0.39)a |
| L(0,25) | 2.17 (0.12) | 0.06 (2.00)a | |
| L(4,1) | 1.23 (0.15) | 3.01 (0.09)a | |
| L(0,4), before dosing day 8 | 0.71 (0.15) | 2.98 (0.08)a | |
| L(0,4), after dosing day 8 | 0.32 (0.06) | 0.23 (0.40) | |
| L(15,10) | Carcass | 89.9 (0.09) | 438 (0.05)a |
| L(0,15) | 14.1 (0.11) | 5.80 (0.07)a | |
| L(5,1) | 6.06 (0.04) | 7.24 (0.04)a | |
| L(0,5) | 0.29 (0.04) | 0.31 (0.03) | |
| L(0,16) | Stomach | 5.06 (0.03) | 5.00 (0.05) |
| L(6,1) | 1.50 (0.68) | 0.57 (1.71) | |
| L(0,6), before dosing day 8 | 3.72 (0.05) | 1.37 (1.71) | |
| L(0,6), after dosing day 8 | 3.72 (0.05) | 0.14 (0.06)a | |
| L(17,10) | Intestine | 10.2 (0.07) | 327 (0.15)a |
| L(0,17) | 2.79 (0.09) | 7.91 (0.14)a | |
| L(7,1) | 2.26 (0.04) | 9.77 (0.10)a | |
| L(0,7), before dosing day 8 | 0.29 (0.02) | 1.00 (0.11)a | |
| L(0,7), after dosing day 8 | 0.39 (0.05) | 0.29 (0.03)a | |
| IC(16) | Stomach | 0.36 (0.05) | 0.32 (0.05) |
| IC(17) | Intestine | 0.02 (0.05) | 0.00 (0.00) |
The data are fractional transfer coefficients [L(I,J)s or the fraction of retinol in compartment J that is transferred to compartment I each day (estimated FSDs in parentheses)] predicted by the forcing function model (model 1; shown in Fig. 3), which is composed of six compartmental models developed for liver, lung, kidney, carcass, stomach, and intestine with forcing function applied. L(I,10)s represent the fraction of plasma retinyl ester in CM/CM remnants that is taken up/cleared by tissues each day. L(0,I)s [L(0,12), L(0,13), L(0,25), L(0,15), and L(0,17)] are the fraction of retinol that leaves tissues after being processed each day that came from CM. L(I,1)s are the fraction of retinol that is transferred from plasma into tissues each day. L(0,I)s [L(0,2), L(0,3), L(0,4), L(0,5), L(0,6), and L(0,7)] represent the fraction of recycled retinol that leaves tissues each day. IC(16) and IC(17) are the calculated fraction of the dose at t0 in stomach and intestine, respectively.
Indicates significant differences (P < 0.05) from the control group.