TABLE 3.
Percentage of traced masses in organs predicted by forcing function model (model 1) and measured total retinol mass in liver and lung of oil-treated neonatal rats in the first 2 days after [3H]retinol dose administration
| M(I) | Tissue | Percentage (%) | Model-Predicted Value | Measured Total Retinol Mass in the Tissue |
| nmol | nmol | |||
| M(2) | Liver | 48.4% | 12.7 | 15.0 |
| M(3) | Lung | 1.91% | 0.50 | 0.35 |
| M(4) | Kidney | 2.66% | 0.70 | ND |
| M(5) | Carcass | 32.8% | 8.64 | ND |
| M(6) | Stomach | 0.63% | 0.17 | ND |
| M(7) | Intestine | 12.0% | 3.17 | ND |
The data are model-predicted retinol masses [M(I)s] in liver, lung, kidney, carcass, stomach, and intestine of [3H]retinol in oil-treated neonatal rats in the first 2 days after dose administration. Pups’ ages were from pnd 4 to 6 during this period. Traced masses were predicted by the forcing function model (model 1) after including the plasma retinol pool size [M(1)] obtained from UPLC results in a steady-state solution in WinSAAM. Percentage is calculated by M(I)/[M(1) + M(2) + M(3) + M(4) + M(5) + M(6) + M(7)] × 100%. ND, not determined.