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. 2014 Jul 24;10(7):e1004436. doi: 10.1371/journal.pgen.1004436

Figure 6. Gene noise and expression plasticity is elevated at the subtelomere in C. albicans.

Figure 6

(A) A schematic identifies the ectopic location of subtelomeric Nup49-GFP and internal Tloα9-GFP in the gene position swap. (B) Fluorescence microscopy was performed for Nup49-GFP and Tloα-GFP at either the NUP49 or TLOα9 locus. GFP expression was stronger and more uniform for either gene at the NUP49 locus compared to the subtelomeric TLOα9 locus. (C) GFP expression from (B) was quantified for 100 cells from 2 biological replicates. Expression of either gene at the NUP49 locus was higher than at the TLOα9 locus. (D) Flow cytometry of Nup49-GFP and Tloα9-GFP also indicated reduced expression, increased expression plasticity, and increased noise at the subtelomeric TLOα9 locus compared to the internal NUP49 locus. * denotes p<0.05. ** denotes p<0.01.