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. Author manuscript; available in PMC: 2014 Jul 24.
Published in final edited form as: Med Image Comput Comput Assist Interv. 2013;16(0 3):600–607. doi: 10.1007/978-3-642-40760-4_75

Fig. 1.

Fig. 1

3D maps of percent tissue change for each additional genetic variant in the interaction in ADNI. Only significant regions are shown after correcting for multiple comparisons with searchlight FDR [25] at a 5% false discovery rate. Images follow radiological orientation. The origin is placed at the Posterior-Right-Inferior corner. Cooler colors over the tissue represent tissue expansion (larger regional brain volume) compared to an average template. There is a clear protective effect of the epistatic loadings bilaterally in the temporal (# in the figure) and occipital lobes (## in the figure): as the number of alleles a subject has increases, the amount of local brain tissue they have is also increased on average.