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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Medchemcomm. 2014 May 6;5(6):826–830. doi: 10.1039/C4MD00126E

Table 2.

GPAT Inhibition by 5-Substituted Derivativesa

graphic file with name nihms600144t2.jpg
Compound R IC50 (µM) ± SD
13a o-Cl 14.4 ± 1.3
13b m-Cl 8.9 ± 0.9
13c p-Cl 9.2 ± 0.7
13d p-n-C4H9 9.0 ± 0.4
13e o-C6H5 10.1 ± 0.7
13f p-C6H5 29.1 ± 6.3
13g o-OCH3 27.6 ± 2.0
13h p-OCH3 19.5 ± 5.5
13i o-F 34.6 ± 2.0
13j m-F 37.6 ± 9.7
13k o-OH 61.7 ± 13.8
13l p-OH 47.3 ± 6.4
a

A description of assay conditions can be found in the Supplemental Information.