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. 2014 Jul 24;8(7):e2970. doi: 10.1371/journal.pntd.0002970

Figure 6. Depletion of MVA-CHIK immune CD4+ T cells, but not CD8+ T cells, abolished the protective immunity afforded by MVA-CHIK in A129 mice.

Figure 6

A129 mice were depleted of CD4+ or CD8+ T cells with anti-CD4 or CD8 mAbs and were then challenged with 500 TCID50 units of CHIK-LR i.d. via the left hind footpad on day 14 post boost. Mice were monitored for (A) footpad swelling; (B) survival and (C) Viremia (measured 2 d.p.i by TCID50 assay). The dotted line indicates the limit of detection of the assay.