Table 2. Validation of prediction using pathological items.

	H-scored	H-scorem
#Samples	124	124
Accuracy	89.5±5.5	79.8±7.1
Sensitivity	94.3±4.1	95.8±3.5
Specificity	77.8±7.3	57.7±8.6
PPV	91.2±4.9	75.8±7.4
NPV	84.8±6.3	90.9±4.9
FDR	8.8±4.9	24.2±7.4

The first column shows the concordance between the high confidence predicted liver samples that were treated for 29 days at the highest dose level and fully data-driven histopathological score (H-score_d), whereas the second column indicates the concordance with the manually derived score (H-score_m).