Table 3. Construction of the ABE4-Score.

		Risk factors present
Group	ABE4-Score	Age ≥70	Bulk ≥7.5	ECOG ≥1	N (%)	HR	P-value
I	0	0	0	0	51 (13.5)
Ii	I	1	0	0	22 (5.8)	1.52	0.6444
iii		0	1	0	14 (3.7)	2.56	0.3028
Iv		0	0	1	89 (23.5)	5.17	0.0073
V	II	1	1	0	7 (1.8)	14.77	0.0004
vi		1	0	1	81 (21.4)	8.17	0.0005
vii		0	1	1	61 (16.1)	6.61	0.0023
viii	III	1	1	1	54 (14.2)	18.90	<0.0001

Presence (1) or absence (0) of the three risk factors stratifies the population into eight groups (Group i–viii). The ABE4-Score is defined as the number of risk factors present in the patient. Results of the univariate Cox regression analysis: hazard rate (HR) and P-value with reference group being Group i (ABE4-Score = 0).