Table 5. Diagnostic performance of autoantibodies against HSP70, RNH1 and ENO1 in pairwise comparisons between CCA, cholangitis, or healthy controls.

Diagnosis	AUC	Cutoff (OD)	Sensitivity (%)	95%CI	Specificity (%)	95% CI	P-value
Healthy vs CCA
HSP70	0.9158	0.2630	93.55	78.58−99.21	73.91	51.60−89.77	<0.0001
ENO1	0.8576	0.7185	80.65	62.53−92.55	78.26	56.30−92.54	<0.0001
RNH1	0.8380	0.5615	93.55	78.58−99.21	66.67	44.68−84.37	<0.0001
Healthy vs cholangitis
HSP70	0.8170	0.2695	75	42.81−94.51	73.91	51.60−89.77	0.002
ENO1	0.8043	0.7380	75	42.81−94.51	78.26	56.30−92.54	0.003
RNH1	0.7790	0.5785	83.33	51.59−97.91	65.22	42.73−83.62	0.007
Cholangitis vs CCA
HSP70	0.7191	0.4800	51.61	33.06−69.85	83.33	51.59−97.91	0.02

AUC  =  area under the curve, 95%CI = 95% confidence interval (lower-upper).