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. Author manuscript; available in PMC: 2014 Jul 24.
Published in final edited form as: Oncogene. 2010 Nov 8;30(11):1341–1350. doi: 10.1038/onc.2010.513

Figure 3. Immunoprofiling of glial tumors.

Figure 3

All tumors show similar immunoprofiles, with slight variation in the expression of individual markers. (a–c) GFAP; (d–f) Olig2; (g–i) doublecortin, (j–l) synaptophysin; (m–o) CD15 (LeX). The MEK-GF + CRE induced tumor shows a loss of GFAP expression in a subset of cells, a feature that can be seen in anaplastic gliomas, such as oligoastrocytomas (OA) or even anaplastic astrocytomas (AA). There is expression of Olig-2 and doublecortin, but no expression of synaptophysin in the tumor tissue and very little CD15 expression. The MEK-GF + AKT induced gliomas show variable expression of Olig2 and doublecortin. The tumor cells are negative for synaptophysin and CD15. Representative images are shown. The scale bar represents 160 μm.