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. 2014 Jul 24;9(7):e103277. doi: 10.1371/journal.pone.0103277

Figure 3. Fxyd3 expression is not regulated by exendin-4 or forskolin in adult islets.

Figure 3

Primary islets from adult control (A, B) and dKO (C, D) mice were incubated with DMSO (vehicle) or 10 µM forskolin (fsk) for the indicated periods of time after O/N rest. Then, RNA (A, C) or proteins (B, D) were extracted for quantitative analysis of Fxyd3 expression. Data are mean ± sem, n = 3 to 4. (E) Induction of IGF1-R expression in control islets after 18 hours of forskolin treatment. (F) Fxyd3 is down-regulated during post-natal development in control but not in dKO islets. Neonates were 3 to 4 days-old. Data are mean ± sem, n = 10 to 11 samples per group, ***p<0,001.