Table 1.
Percentages of time with gastric pH above 3 and 4, and gastric acid concentrations for the 24-hour, diurnal and nocturnal periods following a single dose of placebo, 20 mg omeprazole (O) or 20 mg rabeprazole (R) in 18 obese volunteers
| Rabeprazole | Omeprazole | Placebo | p R vs. O | |
|---|---|---|---|---|
|
% time above pH3
| ||||
| • 24-hour period |
46.5 (37.3-54.9) |
29.7 (15.2-55.5) |
8.8 (4.8-10.8) |
0.10 |
| • Diurnal period |
52.1 (36.4-67.8) |
32.3 (14.9-64.0) |
10.2 (6.2-15.1) |
0.08 |
| • Nocturnal period |
38.2 (24.2-56.6) |
29.5 (6.7-49.2) |
4.1 (1.9-13.2) |
0.25 |
|
% time above pH4 | ||||
| • 24-hour period |
33.4 (27.2-44.3) |
21.3 (10 .1-38.9) |
5.3 (2.5-8.2) |
0.24 |
| • Diurnal period |
37.9 (25.1-49.7) |
20.1 (9.8-48.6) |
4.6 (1.8-8.5) |
0.21 |
| • Nocturnal period |
27.7 (14.0-49.3) |
20.1 (3.3-37.4) |
3.1 (0.2-10.6) |
0.46 |
|
Acid concentration [H
+
] mmol/l
| ||||
| • 24-hour period |
22 (14–53) |
54 (19–130) |
95 (73–170) |
0.01 |
| • Diurnal period |
27 (9–57) |
53 (10–81) |
97 (64–150) |
0.05 |
| • Nocturnal period | 29 (18–48) | 57 (23–160) | 115(76–180) | 0.01 |
Values are medians and Interquartiles (Q1-Q3).