FIGURE 1.

Experimental Design. At 8-weeks of age twenty-four female C57BL/6 mice were randomly assigned to non-irradiated control, four fractionated doses of 4 Gray (4x4 Gy; BED 37 Gy), or a single 16 Gy dose (16 Gy; BED 100 Gy) based on the total biological effective dose (BED). Mice were sacrificed 2-weeks after the first radiation exposure. All mice underwent sham or radiation exposure starting on day 1. Mice receiving fractionated doses (4x4 Gy) were irradiated every other day over a period of 2 weeks. Mice receiving a single radiation (16 Gy) were only irradiated on day 1. Grip strength was performed in the morning prior to sacrifice. ^* = 4 Gy radiation exposure; ^** = 16 Gy radiation exposure.