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. Author manuscript; available in PMC: 2014 Jul 24.
Published in final edited form as: Curr Oncol Rep. 2009 Jan;11(1):73–80. doi: 10.1007/s11912-009-0012-8

Figure 1.

Figure 1

Model for diffuse large B-cell lymphoma pathogenesis. Only the most common genetic lesions and their frequencies are shown. Genetic lesions more specific for primary central nervous system lymphoma (PCNSL) include somatic hypermutations as well as chromosomal translocations, especially those involving the IgH and BCL-6 genes. TP53 mutations are rare in PCNSL. (Adapted from Lossos [13].)