. Author manuscript; available in PMC: 2014 Jul 24.

Published in final edited form as: Curr Oncol Rep. 2009 Jan;11(1):73–80. doi: 10.1007/s11912-009-0012-8

Table 1.

Immunohistochemistry for germinal center–related antigens

Antigen	Positive PCNSL cases, n/n (%)	Comment
bcl-6	26/33 (79)	The bcl-6 protein is a zinc-finger transcriptional repressor encoded by the BCL-6 gene
CD10	6/32 (19)	CD10 is a marker that reflects GC origin in reactive lymphoid tissue and lymphomas
MUM1	31/32 (97)	MUM1 is a late GC/early post-GC marker
CD44	11/31 (35)	CD44 is expressed most strongly by post-GC mantle zone cells
vs38c	4/33 (12)	The presence of vs38c and CD138 denotes plasmacytic and/or post-GC differentiation
CD138	0/32 (0)	The presence of vs38c and CD138 denotes plasmacytic and/or post-GC differentiation
BCL-2	27/29 (93)	BCL-2 protein expression prevents cellular apoptosis and is downregulated by normal GC cells

GC—germinal center; PCNSL—primary central nervous system lymphoma.

(From Braaten et al. [20].)