Skip to main content
. Author manuscript; available in PMC: 2014 Jul 24.
Published in final edited form as: Curr Oncol Rep. 2009 Jan;11(1):73–80. doi: 10.1007/s11912-009-0012-8

Table 2.

Selected genetic factors in primary central nervous system lymphoma and their biologic and prognostic significance

Gene Biologic effects Possible clinical significance
ECM family:
 SPP1 and CHI3L1 		CNS tropism, B-cell migration, lymphoproliferation, cell
differentiation, migration, angiogenesis, and metastasis		 Aggressive tumor growth, high metastatic
potential, poor prognosis
STAT6 Expressed in tumor tissue and endothelium Overexpression associated with aggressive
tumor growth, decreased survival in
patients treated with methotrexate
PRDM1 Tumor suppressor gene, regulation of B-cell differentiation Mutations associated
with lymphomagenesis
p14 ARF Induction of cell growth arrest and stabilization
of p53 protein		 Deletion or promoter methylation can
induce tumor growth
PTPRK Regulation of cell contact and adhesion Shorter survival in patients with loss
of expression
BCL-6 Transcriptional repressor, oncogene, malignant
transformation of germinal center B cells		 Overexpression associated with
favorable prognosis

CNS—central nervous system; ECM—extracellular matrix.