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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Leuk Lymphoma. 2014 Nov;55(11):2538–2548. doi: 10.3109/10428194.2014.883073

Figure 2.

Figure 2

(A) Delineation of 17p boundaries revealed by aCGH in prominent AML cases showing loss of chromosome 17p. The top panel shows an ideogram of chromosome 17 with the p-arm to the left and q-arm to the right. The section of chromosome marked with vertical line is expanded to show the plot of array CGH data for the 17p13.1 sub-band. Precise mapping of this chromosomal breakpoint revealed AML cases with loss of TP53 gene which was shown to be as complete loss of chromosome 17 [del(17)] by conventional karyotyping. Loss was shown in red color. (B) Validation of 11 cases showing one copy loses in 8 of 11 cases and homozygous loss in 1 of 11 cases at 17p for candidate genes TP53 (17p13.1) for TP53, 7 of 11 with one copy loss and 1 of 11 with homozygous loss for NCOR (17p11.2) gene, 4 of 11 for RFFL (17q12), 1 of 11 for MRPS 23 17q22 and no loss of ACOX1 (17q25.1) by RT-PCR based copy number analysis.