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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Circ Heart Fail. 2013 Oct 9;6(6):1250–1258. doi: 10.1161/CIRCHEARTFAILURE.113.000632

Figure 1. Pharmacological decomposition of CXL-1020.

Figure 1

A) Decomposition of CXL-1020 in aqueous solution into HNO (measured by nitrous oxide) and CXL-1051. Conversion is rapid, and virtually complete by 15 minutes, with stoichiometry confirming pure generation of HNO and CLX-1051 in equal parts. B) Decomposition of CXL-1020 in human whole blood shows similar rapid pharmacokinetics. IS: internal standard, see supplemental methods.