Table.
Hemodynamic variables and plasma biomarkers during 4-hr infusion of CXL-1020 in dogs with ischemic cardiomyopathy
| Vehicle Control (n=6) | 3 µg/kg/min | 10 µg/kg/min | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline | 4 hours | Washout | Baseline | 4 hours | Washout | Baseline | 4 hours | Washout | |
| Heart Rate (bpm) | 75±4 | 69±1 | 71±3 | 74±2 | 75±5 | 65±1 | 74±1 | 77±2 | 75±5 |
| Systolic AoP (mmHg) | 89±3 | 84±4* | 81±2 | 91±2 | 82±1 | 80±1 | 92±6 | 82±3 | 84±2 |
| Diastolic AoP (mmHg) | 62±3 | 55±3 | 57±4 | 64±2 | 55±2* | 53±1* | 64±4 | 50±1* | 53±1 |
| Mean AoP (mmHg) | 75±3 | 71±4 | 68±3 | 76±2 | 68±2* | 66±1* | 77±5 | 63±2* | 65±2* |
| LVEDP (mmHg) | 13.7±0.8 | 15.3±0.7 | 12.3±1.0 | 14.5±0.7 | 13.3±0.3 | 13.8±0.7 | 13.8±0.3 | 10.8±0.9* | 11.7±1.5 |
| LVESV (mL) | 47.8±1.0 | 47.8±1.0 | 47.7±1.1 | 47.7±1.1 | 36.5±2.1* | 37.8±2.4* | 48.0±1.2 | 32.8±1.9* | 34.3±2.5* |
| LV EDV (ml) | 66.0±1.3 | 65.8.0±1.3 | 65.7±1.4 | 66.0±1.3 | 58.8±2.1* | 59.5±2.2* | 66.0±1.5 | 55.8±0.9* | 55.8±2.1* |
| LV FAS (%) | 25.0±0.4 | 25.3±0.7 | 25.2±0.7 | 25.5±0.3 | 35.8±2.1* | 33.5±2.3* | 24.8±0.3 | 38.8±2.2* | 35.3±2.8* |
| Stroke Volume (mL) | 18.2±0.3 | 18.0±0.4 | 18.0±0.4 | 18.3±0.3 | 22.3±1.1* | 21.7±1.0* | 18.0±0.4 | 23.0±1.3* | 21.5±1.5* |
| SVR (dynes.sec.cm5) | 4476±328 | 4640±405 | 4283±200 | 4502±142 | 3335±247* | 3793±234* | 4642±236 | 2904±138* | 3342±311* |
| Deceleration Time (msec) | 93.2±2.5 | 96.3±3.0 | 96.7±3.6 | 94.8±3.8 | 119.8±5.3* | 103.3±2.3* | 97.3±4.0 | 128.0±7.5* | 121.3±6.9* |
| Peak Power Index (mmHg/sec*mL)*100 | 184±12 | 171±10 | 169±9 | 192±11 | 245±19* | 212±14 | 180±14 | 262±16* | 250±20* |
| MVO2 (µmol/min) | --- | --- | --- | --- | --- | --- | 102.5±6.3 | 71.5±14.5* | --- |
| nt-proBNP (fmols/mL) | 165±12 | 164±13 | --- | 164±15 | 133±11* | --- | 166±13 | 93±16* | --- |
| pro-ANP (pmols/mL) | 0.56±0.06 | 0.57±0.06 | --- | 0.57±0.07 | 0.45±0.05* | --- | 0.57±0.06 | 0.31±0.05* | --- |
| TnI (ng/mL) | 0.53±0.03 | 0.56±0.03 | --- | 0.56±0.03 | 0.36±0.03* | --- | 0.58±0.02 | 0.28±0.2† | --- |
AoP=aortic pressure; LV=left ventricular; EDP=end-diastolic pressure; ESV=end-systolic volume; EDV=end-diastolic volume; FAS=fractional area of shortening; SVR=systemic vascular resistance,. MVO2=myocardial oxygen consumption. nt-pro BNP=n-terminal pro-brain natriuretic peptide; pro ANP=pro atrial natriuretic peptide, TnI – troponin I.
*
p<0.05 versus Baseline